Artemisia Iwaymogi Compositae) has been used clinically for jaundice, hepatitis, liver cirrhosis etc. The purposes of present study were to examine pharmacological effects of Artemisia Iwaymogi water extract(AIWE) on biochemical parameters (activities of ALP and LAP, contents of glucose, total bilirubin, total protein and albumin in serum, A/G ratio, and levels of hepatic glycogen) against hepatic injury by catbon tetrachloride(CCl₄) in rats.
The results were as follows ;
1. Increased ALP activities by CCl₄were very significantly(p<0.001) decreased in AIWE posttreatment groups at 72 hours and significantly(p<0.05) decreased in AIWE pretreatment groups at 72 hours. Increased LAP activities by CCl₄ were significantly (p<0.05) decreased in AIWE posttreatment groups at 72 hours. A little increased total bilirubin contents by (CCl₄ were very significantly (p<0.001) decreased in AIWE posttreatment groups at 24, 48 and 72 hours.
2. Increased glucose contents by CCl₄ were decreased in AIWE posttreatment groups. Decreased hepatic glycogen levels by CCl₄, were significantly (p<0.05) increased in AIWE posttreatment groups at 48 and 72 hours.
3. Decreased total protein contents by CCl₄ were significantly (p<0.05) increased in AIWE posttreatment groups at 48, 72 hours. Decreased albumin contents by CCl₄ were increased in proportion to numbers of AIWE treatments in AIWE pre- and posttreatement groups. Decreased A/G ratios by CCl₄ were significantly (p<0.05) increased in AIWE posttreatment groups at 48 hours.
In conclusion, AIWE did not affect normal liver function and had hepatoprotective effects rather than direct preventive effects to CCl₄-induced cholestasis, damages in metabolisms of glucose, protein and bilirubin.
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